大規模脂質組精細結構解析為生命科學研究探索提供新維度

脂質組學已成為科學研究的熱點，采用質譜技術進行脂質組學研究，已能解決諸如脂質的種類鑒別及脂肪酸鏈組成等問題。但是，脂質精細結構，如C=C及sn-位置等，對大規模組學來說仍是一個難點。近年來，區別與定量脂質C=C位置異構體已被證明對于生理過程研究、疾病標志物篩查及新藥研發有著重要意義。PURSPEC Ω Analyzer脂質分析系統旨在為科學家提供一種全新脂質組學新工具，加速脂質標志物的探索發現與應用，前期技術研究成果已被國際知名期刊收錄。

注釋：以上圖片僅供參考，請以實物為準。

參考文獻

[1] Wenpeng Zhang, Donghui Zhang, Qinhua Chen, Junhan Wu, Zheng Ouyang and Yu Xia. “Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers”, Nature Communications, 2019,Online.

[2]Wenpeng Zhang , Spencer Chiang, Zishuai Li, Qinhua Chen, Yu Xia, Zheng Ouyang. “Polymer Coating Transfer Enrichment for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples”, 2019, Online.

[3] Dr. Tiffany Porta?Siegel, Dr. Kim Ekroos, Dr. Shane R. Ellis. “Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics”, Angewandte Chem, 2019,doi:10.1002/anie.201812698.

[4] Xiaoxiao Ma, Leelyn Chong, Ran Ti an, Riyi Shi, Tony Y. Hu, Zheng Ouyang, and Yu Xia. “Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction “, Proceedings of the National Academy of Sciences” Proceedings of the National Academy of Sciences of the United States of America, 2016,113(10):2573.